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KMID : 1034320100010010030
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Sleep Medicine Research
2010 Volume.1 No. 1 p.30 ~ p.31
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Methylphenidate’s Effect on Cerebral Blood Flow in Patients with Narcolepsy
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Yeon Eun
Tae Woo-Suk
Hong Seung-Bong
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Abstract
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We performed 99mTc-ethyl cysteinate dimer brain single-photon emission computed tomography before and after administering methylphenidate, for four weeks, to narcolepsy patients with cataplexy. Cerebral blood flow increased in the bilateral cingulate gyri and both thalami with methylphenidate treatment as compared to pre-methylphenidate treatment. methylphenidate treatment also produced an regional cerebral blood flow increase in the bilateral nucleus accumbens, cingulate gyri, superior frontal gyri, and bilateral amygdalo-hippocampi and parahippocampal gyri as compared to pre-methylphenidate treatment. Moreover, no brain region showed a significant regional cerebral blood flow decrease after methylphenidate treatment.
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KEYWORD
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Narcolepsy, Methylphenidate, Cerebral blood flow
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